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  • Chem Sci Trans., 2015, 4(2),  pp 534-540  

    DOI:10.7598/cst2015.1029

    Research Article

    Synthesis of Some Benzimidazole Derivatives Bearing 1,3,4-Oxadiazole Moiety as Anticancer Agents

  • BEREKET MOCHONA1*, ELIZABETH MAZZIO2, MADHAVEIGANGAPURUM2, NELLY MATEEVA1 and K. K. REDDA2
  • 1College of Science and Technology, Department of Chemistry, 2College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA
  • Abstract

    In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (5a-i) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (5c) exhibited moderate cytotoxicity.

    Keywords

    Benzimidazole, 1,3,4-Oxadizole, Pharmacophore hybridization, Cytotoxcity

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