• image 01
    Volume 1, No.1, 2012
  • image 02
    Volume 1, No.2, 2012
  • image 01
    Volume 1, No.3, 2012
  • image 02
    Volume 2, No.1, 2013
  • image 02
    Volume 2, No.2, 2013
  • image 02
    Volume 2, No.S1, 2013
  • image 02
    Volume 2, No.3, 2013
  • image 02
    Volume 2, No.4, 2013
  • image 02
    Volume 3, No.1, 2014
  • image 02
    Volume 3, No.2, 2014
  • Volume 3, No3
    Volume 3, No.3, 2014
  • Volume 3, No4
    Volume 3, No.4, 2014
  • Volume 4, No1
    Volume 4, No.1, 2015
  • Volume 4, No2
    Volume 4, No.2, 2015
  • Volume 4, No3
    Volume 4, No.3, 2015
  • Volume 4, No4
    Volume 4, No.4, 2015
  • Volume 5, No1
    Volume 5, No.1, 2016
  • image 01
  • image 02
  • Login|Register
  • Chem Sci Trans., 2015, 4(4),  pp 947-954  

    DOI:10.7598/cst2015.1091

    Research Article

    A New Approach to the Synthesis of Cyanamide: 2-Cyanoimino-4-aryl-6-(naphthalen-2-yl)-3,4-dihydro-1H-pyrimidines and their Antimicrobial Screening

  • N.PRAKASH, M.ELAMARAN and N. INGARSAL*
  • P G and Research Department of Chemistry, Rajah Serfoji Govt. College, Thanjavur-05, Tamilnadu, India
  • Abstract

    A series of cyanoiminopyrimidines were synthesized by the reaction of 1-(2-naphthyl)-3-arylprop-2-en-1-ones with cyanoguanidine in the presence of sodium hydroxide in ethanol. The mechanism involves the 1,4 or 1,2-addition of cyanoguanidine to α, β-unsaturated ketone, heterocyclisation and subsequent tautomeric change of formed adduct with loss of water. All the newly synthesized compounds were characterized by IR and NMR spectral studies. The in vitro antimicrobial screening of synthesized compounds showed the significant antifungal activities compared to the standard fluconazole.

    Keywords

    Synthesis, Acetylnaphthalene, Chalcones, Cyanoguanidine, Cyanoiminopyrimidines

    This article has been viwed 1177 times

      

    Citations for this article 0

      

    No Citations