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  • Chem Sci Trans., 2015, 4(4),  pp 1102-1106  

    DOI:10.7598/cst2015.1104

    Research Article

    Spectrophotometric Estimation of Gemcitabine HCl in Pharmaceutical Dosage form via Oxidative Coupling Reaction

  • MALLADI SRINIVAS REDDY* and SADIYA FIRADOUS
  • Department of Pharmaceutical Analysis & Quality Assurance, Vaageswari College of Pharmacy, Karimnagar, TS (505481), India
  • Abstract

    Gemcitabine HCl is an antiviral drug, novel, facile, sensitive and selective spectrophotometric method have been developed for the quantitative estimation of gemcitabine HCl in pharmaceutical formulations with coupling reagent. The proposed method involves the oxidative coupling reaction of gemcitabine HCl with 3-methyl-2-benzothiazolinone hydrazone hydrochloride monohydrate in the presence of ferric chloride and acidic medium to form bluish green colored chromogen at 558 nm. There is no interference observed from the excipients that are present in the Gemcitabine HCl pharmaceutical dosage form with this estimation. The optimum reaction conditions and other important analytical parameters were established

    Keywords

    Gemcitabine HCl, 3-Methyl 1, 2-Benzothiazolinehy-drazone hydrochloride, UV-Visible spectrophotometry

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