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  • Chem Sci Trans., 2015, 4(4),  pp 1057-1065  

    DOI:10.7598/cst2015.1114

    Research Article

    Synthesis, Characterisation, Antimicrobial Evaluation of Chalcones and its Cyclised Product: Phenyl Pyrazolines and Benzodiazepines

  • ANJANI SOLANKEE* and RIKI TAILOR
  • Department of Chemistry, B. K. M. Science College, Valsad-396001 (Affiliated to the Veer Narmad South Gujarat University, Surat) India
  • Abstract

    A conventional root was designed and synthesised for the pyrazolines and benzodiazepines from chalcones. The synthesis of chalcones (7j-n) was accomplished according to the Claisen-Schmidt condensation of substituted acetophenones (C) with various aldehydes. Treatment of this chalcones with phenyl hydrazine hydrochloride / alkali and o-phenylenediamine / glacial acetic acid afforded the corresponding 2- phenyl pyrazoline (8j-n) and 1,5- benzodiazepine (9j-n) derivatives respectively. The structures of all the newly synthesised compounds were established based on IR, 1H NMR, mass spectral data as well as elemental analysis. In vitro antimicrobial proficiency of the title compounds were assessed against selected pathogens. Compounds 7j, 7m, 7n, 8k, 8m and 9m exhibited excellent antimicrobial activity and said to be the most proficient members of the series compared to standard drugs

    Keywords

    Chalcones, Phenyl pyrazolines, Benzodiazepines, Claisen-Schmidt reaction, Antimicrobial activity

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