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  • Chem Sci Trans., 2015, 4(4),  pp 1077-1082  

    DOI:10.7598/cst2015.1116

    Research Article

    Synthesis, Cytotoxic Activity and Molecular Docking Studies of 4-Aryl-6-methyl-3,4-Dihydropyrimidin-2(1H)-ones/thiones with Eg5 Protein

  • DURGA PRASAD BEDA* and GIRIJA SASTRY VEDULA
  • Department of Pharmaceutical Chemistry, AU College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam, Andhra Pradesh-530003, India
  • Abstract

    Various Biginelli compounds (dihydropyrimidinones, DHPM) have been synthesized efficiently and in high yields under mild, solvent free and eco-friendly conditions in a one pot reaction of 1, 3-dicarbonyl compounds, aldehydes and urea/thiourea using sodium dodecyl sulphate (SDS) as a novel catalyst under two experimental conditions have been introduced. Synthesized compounds were evaluated for their cytotoxicity screening in lung cancer (A-549) and colon cancer (HT-29) cell lines by the MTT assay method. Molecular docking studies were carried out synthesized DHPM derivatives using GOLD software with the crystal structure of Eg5 protein (1QOB) to gain some structural insights on the binding mode and possible interaction with the active site.

    Keywords

    Pyrimidine, Cytotoxic activity, Docking studies

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