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  • Chem Sci Trans., 2016, 5(1),  pp 41-55  

    DOI:10.7598/cst2016.1132

    Research Article

    Identification, Charecterization and Quantification of Process Related Impurities in Azimsulfuron Technical

  • M. PRABHU VENKATESH*, V. PARDHASARADHI, V. DHAYANITHI, MANE AVINASH, S. PALIMKAR, R. KADAM SUBHASH and HINDUPUR RAMA MOHAN
  • Advinus Therapeutics Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru-560058, Karnataka, India
  • Abstract

    This manuscript describes identification, isolation and characterization of azimsulfuron impurities. Six impurities ranging from 0.05 to 0.15 % w/w in azimsulfuron technical were detected by a simple reverse phase HPLC method. These impurities were isolated by prep-HPLC and were characterized using IR, 1H NMR, 13C NMR and LC-MS/MS. Based on the results obtained from different spectroscopic experiments, these impurities have been characterized as impurity A (2-amino-4, 6-dimethoxy pyrimidine), impurity B (1-methyl-4-(2-methyl-2H-tetrazol-5-yl)-1H-pyrazole-5-sulfonamide) impurity C (phenol), impurity D (N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-1-methyl-4-(1-methyl-1H-tetrazol-5-yl)-1H-pyrazole-5-sulfonamide), impurity E (1,3-bis(4,6-dimethoxypyrimidin-2-yl)urea) and impurity F (phenyl (4,6-dimethoxypyrimidin-2-yl) carbamate).

    Keywords

    Azimsulfuron, Prep-HPLC, Impurities, Spectroscopy, Identification, Characterization

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