Abstract

Albendazole (1) is a broad-spectrum anthelmintics drug. Albendazole impurity A, 5-(propylthio)-1H-benzimidazol-2-amine (6), impurity B, methyl [5-(propylsulfinyl)- 1H-benzimidazol-2-yl]carbamate (7), impurity C, methyl [5-(propylsulfonyl)-1H- benzimidazol-2-yl]carbamate (8) and impurity D, 5-(propylsulfonyl)-1H- benzimidazol-2-amine (9) are degradation or metabolic impurities whereas impurity E, methyl 1H-benzoimidazol- 2-yl)carbamate (11) and impurity F, methyl [5-(methylthio)-1H- benzimidazol-2-yl]carbamate (15) are process related impurities. All these impurities are listed in European pharmacopoeia. Present work describes the synthesis and characterization of all these six impurities

Keywords

Albendazole, Impurities, Synthesis, Characterization