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  • Chem Sci Trans., 2016, 5(1),  pp 79-86  

    DOI:10.7598/cst2016.1146

    Research Article

    Synthesis and Characterization of Impurities of an Broad- Spectrum Anthelmintic Drug, Albendazole

  • SABRINTAJ KALAS, SURYAKANT PATIL* and VIDYADHAR JADHAV
  • Prof. Dr. S. C. Bhattacharya Organic Synthesis Laboratory, VerGo Pharma Research Lab. Pvt. Ltd., Plot B5, Phase 1A, Verna Industrial Estate, Verna, Salcette, Goa-403 722, India
  • Abstract

    Albendazole (1) is a broad-spectrum anthelmintics drug. Albendazole impurity A, 5-(propylthio)-1H-benzimidazol-2-amine (6), impurity B, methyl [5-(propylsulfinyl)- 1H-benzimidazol-2-yl]carbamate (7), impurity C, methyl [5-(propylsulfonyl)-1H- benzimidazol-2-yl]carbamate (8) and impurity D, 5-(propylsulfonyl)-1H- benzimidazol-2-amine (9) are degradation or metabolic impurities whereas impurity E, methyl 1H-benzoimidazol- 2-yl)carbamate (11) and impurity F, methyl [5-(methylthio)-1H- benzimidazol-2-yl]carbamate (15) are process related impurities. All these impurities are listed in European pharmacopoeia. Present work describes the synthesis and characterization of all these six impurities

    Keywords

    Albendazole, Impurities, Synthesis, Characterization

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