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  • Chem Sci Trans., 2016, 5(1),  pp 207-217  

    DOI:10.7598/cst2016.1149

    Research Article

    Synthesis and Characterization of Novel Oxadiazole and Pyrazole Hybrids as Potential Antimicrobial Agents

  • M. MAHESH, G. BHEEMARAJU, G. MANJUNATH and P. VENKATA RAMANA
  • Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu ? 515 003, Andhra Pradesh, India
  • Abstract

    As a part of our ongoing research in the exploration of novel antimicrobial agents, we report herein novel synthesis of hybrid molecules 4-methyl-7-(2-oxo-2-(5-(substitutedthio)-1,3,4-oxadiazol-2-yl)ethoxy)-2H-chromen-2-ones and 4-substitutedbenzylidene-3-methyl-1-(2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetyl)-1H-pyrazol-5(4H)-ones by combining coumarin ring with 1,3,4-oxadiazole and pyrazole scaffolds respectively. All the synthesized compounds have been characterized by chemical analysis, IR, 1H NMR, 13C NMR and mass spectroscopy. All the compounds have been evaluated for their in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli and fungi Aspergillus niger using serial broth dilution method. All the synthesized compounds displayed antimicrobial activity. Among all the compounds 7c and 7d have been emerged as highly potent molecules with 75 μg/mL potency

    Keywords

    Oxadiazoles, Pyrazoles, Knoevenegel condensation, Coumarin derivatives, Antimicrobial activity

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