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  • Chem Sci Trans., 2012, 1(1),  pp 185-193  

    DOI:10.7598/cst2012.115

    Research Article

    Synthesis, Metal Ions Coordination, Antimicrobial Activity of Some L-Tartaric Acid Derivatives

  • ZOULIKHA KHIATI, ABDELHAK CHERCHAR and ADIL A OTHMAN?
  • Laboratory of Bioactive Organic Chemistry-LCOB-, Department of Chemistry, Faculty of Science, University of Science and Technology-Mohamed Boudiaf-Oran,
    USTO-MB.B.P.1505 ElMnaouer, 31000, Oran, Algeria
  • Abstract

    The bis- 1,3,4-oxadiazole-thione and bis-4-amino-1,2,4-triazole-thiol derivatives from l-tartaric acid were synthesized. The synthetic intermediates, ester, hydrazide and oxadiazole derivatives have shown a significant tendency to form complexes with Fe(III),Ni(II) and Cu(II) ions. The formation of complexes with metals was detected by UV-Vis and IR spectroscopy. A novel complex nucleoside from bis-4-amino-1,2,4-triazole-thiol derivative with l-arabinose was also synthesized. The antimicrobial activity for final and synthetic intermediates in vitro against the microorganisms: Escherichia coli, Pseudomonas aeruginosa, Yersinia pseudotuberculosis, Enterococcus faecalis, Staphylococcus aureus and Candida albicans were examined and some products showed noticeable activity against the tested microorganisms.

    Keywords

    1,3,4-Oxadiazole-thione, 1,2,4-Triazole-thiol, L-Tartaric acid, Antimicrobial activity, Complex formation

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