Abstract

In the present investigation, a series of some novel 3,5-diaryl-N-chalcone-2-pyrazoline derivatives (6a-g) have been synthesized by the treatment of 4,5-dihydro-3-(2-hydroxyphenyl)-5-(6-methoxynaphthalen-5-yl)pyrazole-1-carbaldehyde (4a-g) with 2-hydroxy-4-chloro acetophenones (5) in presence of sodium hydroxide. The structure of newly synthesized compounds was confirmed by the IR, ¹H NMR and Mass spectral analysis. All these newly synthesized compounds were evaluated for their in vitro antimicrobial activity. Most of the compound showed potent activity.

Keywords

2-Pyrazoline-1-carboxaldehyde, N-Chalcone, Formic acid, Hydrazine hydrate, Antibacterial, Antifungal activity