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  • Chem Sci Trans., 2016, 5(1),  pp 109-116  

    DOI:10.7598/cst2016.1159

    Research Article

    Synthesis of Some Novel 3, 5-Diaryl-N-chalcone-2-pyrazoline Derivatives and Evaluation of their Antimicrobial Activity

  • SATISH BABULAL JADHAV* and SHANTILAL D. RATHOD
  • P. G. Department of Chemistry, Milind College of Science, Aurangabad-431002, Maharashtra, India
  • Abstract

    In the present investigation, a series of some novel 3,5-diaryl-N-chalcone-2-pyrazoline derivatives (6a-g) have been synthesized by the treatment of 4,5-dihydro-3-(2-hydroxyphenyl)-5-(6-methoxynaphthalen-5-yl)pyrazole-1-carbaldehyde (4a-g) with 2-hydroxy-4-chloro acetophenones (5) in presence of sodium hydroxide. The structure of newly synthesized compounds was confirmed by the IR, 1H NMR and Mass spectral analysis. All these newly synthesized compounds were evaluated for their in vitro antimicrobial activity. Most of the compound showed potent activity.

    Keywords

    2-Pyrazoline-1-carboxaldehyde, N-Chalcone, Formic acid, Hydrazine hydrate, Antibacterial, Antifungal activity

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