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  • Chem Sci Trans., 2016, 5(1),  pp 125-136  

    DOI:10.7598/cst2016.1162

    Research Article

    Synthesis of New Pyrazole Derivatives Containing 2-Methylquinoline Ring System: A Novel Class of Potential Antimicrobial Agents

  • G. BHEEMA RAJU, M. MAHESH, G. MANJUNATH and P. VENKATA RAMANA*
  • Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu - 515 003, Andhra Pradesh, India
  • Abstract

    Two series of diversely substituted 1-(3,5-dimethyl-4-(substitutedphenyldiazenyl)-1H-pyrazol-1-yl)-2-((2-methylquinolin-8-yl)oxy)ethanones (8a-g) and 3-methyl-1-(2-((2-methyl-quinolin-8-yl)oxy)acetyl)-4-(2-substitutedphenylhydrazono)-1H--pyrazol-5(4H-)-ones (9a-h) were synthesized. All the newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, Mass and chemical analysis. The compounds were evaluated for their in vitro<.i> antibacterial activity against some Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis, Gram-negative bacteria, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and screened for antifungal activity against Aspergillus niger, Ustilago maydis using the agar disc diffusion method. All the tested compounds showed significant antibacterial activity against both the strains with compounds 8d and 9d being more potent

    Keywords

    2-Methylquinolin-8-ol, 2-((2-Methylquinolin-8-yl)oxy) acetohydrazide, Azopyrazoles, hydrazonopyrazolin-5-ones, Antibacterial and antifungal activities

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