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  • Chem Sci Trans., 2012, 1(1),  pp 53-56  

    DOI:10.7598/cst2012.117

    Research Article

    Convenient Preparation of Mono-2 or Mono-3-O-Benzoyl--Cyclodextrin Dependent the Solvent Equilibrium

  • ZHI-ZHONG WANG
  • Engineering Research Center for Hui Medicine Modernization, School of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia, 750004, P. R. China
  • Abstract

    A new and convenient method is presented for the preparation of mono-2 or mono-3-O-benzoyl--cyclodextrin by direct benzoylation of -cyclodextrin on the secondary hydroxyl face using N-benzoylimidazole in carbonate buffer solution. These processes involved the solvent-dependent equilibriums of isomerization to improve the yields. Among the common solvents
    (N,N-dimethylform-amide, dimethyl sulfoxide and H2O), dimethyl sulfoxide is the most advantageous for preparing mono-2-O-benzoyl--cyclodextrin and H2O is the most advantageous for preparing mono-3-O-benzoyl--cyclodextrin.

    Keywords

    Cyclodextrin, Benzoylation, Isomerization, Equilibrium

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