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  • Chem Sci Trans., 2016, 5(2),  pp 442-446  

    DOI:10.7598/cst2016.1198

    Research Article

    Mild and Efficient Condition for Synthesis of Gabapentin Impurity B and E

  • DIPAK VARAL, DEEPAK PANMAND* and VIDYADHAR JADHAV
  • Prof. Dr. S. C. Bhattacharya Organic Synthesis Laboratory, VerGo Pharma Research Lab. Pvt. Ltd., Plot B5, Phase 1A, Verna Industrial Estate, Verna, Salcette, Goa-403722, India
  • Abstract

    Gabapentin (1), a widely prescribed anticonvulsant used to treat epilepsy and neuropathic pain. This work describes the synthesis of two potential Gabapentin impurities as per USP and EP. Gabapentin impurity B; 2-(1-cyanocyclohexyl) acetic acid (2) was synthesized by oxidative dehydrogenation of Gabapentin API using trichloroisocyanuric acid. Impurity E; 1-(carboxymethyl) cyclohexanecarboxylic acid (3) was obtained by acid hydrolysis of 2. These impurities are characterized by IR, mass spectral data, HPLC RRT and 1H NMR

    Keywords

    Gabapentin, Anticonvulsant, Impurity, Synthesis, Characterization

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