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  • Chem Sci Trans., 2016, 5(1),  pp 265-271  

    DOI:10.7598/cst2016.1202

    Research Article

    Synthesis, Characterization and Antimicrobial Activity of 5-Substituted indole-2,3-dione Based 4 -Thiazolidione Derivatives

  • A. ZAHIR HUSSAIN1, M. NAGOOR MEERAN2* and A. SANKAR3
  • 1PG and Research Department of Chemistry, Jamal Mohamed College, Trichy, India
    2PG and Research Department of Chemistry, Vivekanandha College of Arts and Sciences for Women (Autonomous), Tiruchengode, India
    3Department of Chemistry, Kandaswami Kandar?s College, P. Velur, Namakkal, India
  • Abstract

    A series of 5-substituted indole- 2,3-dione based spiro-4-thiazolidiones were synthesized, characterization and evaluated for their antimicrobial activity. Condensation of 5-substituted indole-2,3-dione with substituted primary aryl amine was formed series of Schiff bases (1) which on reaction with thioglycolic acid and thiolactic acid in 1,4-dioxane afforded the formation of the corresponding 4-thiazolidinones (2, 3). All the synthesized compounds were characterized on the basis of their IR, 1H and 13C NMR and elemental analysis. The antimicrobial activity of all the compounds (D01-D04, E01-E04) showed significant activity against the selected micro organisms

    Keywords

    5-Substituted indole -2,3-dione, Spiro-4-thiazolidiones, Antimicrobial

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