In this work, we selected three dimensional structure of Peptidoglycon which plays an important role in staphylococcus pathway. The protein structures were collected from PDB data bank. From the 3D structures of the proteins, the targeted derivatives were designed. Docking studies was performed with designed ligands from the drug. The drug derivatives docked to the protein by hydrogen boding interactions and these interactions play an important role in the binding studies. Docking results showed the best compounds among the derivatives.
Antibacterial activity, Docking studies, Peptidoglycon, Nitroimidazo[1,2-b]pyridazine.