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  • Chem Sci Trans., 2012, 1(1),  pp 162-165  

    DOI:10.7598/cst2012.123

    Research Article

    Disulphide Bond Containing Oligodeoxynucleotide Stabilizes DNA:RNA Duplex Structure

  • AJAY KUMAR
  • Galgotias University, Plot No. 2, Sector17A, Yamuna Expressway, Distt. Gautam Budh Nagar, UP, India
  • Abstract

    Thermal stability of DNA: RNA duplex formation of disulphide bond containing oligodeoxynucleotide was studied using UV thermal melting (Tm). The disulphide bond containing oligodeoxynucleotide increased the melting temperature of DNA:RNA duplex by 9.5 oC to duplex containing unmodified oligodeoxynucleotide. The DNA: RNA duplex stability of disulphide bond containing oligodeoxynucleotide was also enhanced by 3 oC relative to duplex containing C-5 propyne deoxyuridine substituted oligodeoxynucleotide.

    Keywords

    C-5 Thiopropyne thymidine substituted oligodeoxynucleotides, Tm, C-5 propynedeo-xyuridine oligodeoxynucleotide, Disulphide bond containing oligonucleotide.

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