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  • Chem Sci Trans., 2016, 5(3),  pp 587-594  

    DOI:10.7598/cst2016.1234

    Research Article

    Synthesis, Characterization and Antimicrobial Screening of Metal Complexes of Mannich Bases Derived from Benzimidazole

  • A. ABDUL JAMEEL, M. SYED ALI PADUSHA, K. SULTHAN SYED IBRAHIM* and S. SAJENA
  • Department of Chemistry, Jamal Mohamed College, Tiruchirappalli-620020, Tamilnadu, India
    Department of Chemistry, Dr. Zakir Husain College, Ilayangudi - 630702, Tamilnadu, India
  • Abstract

    Co(II), Ni(II), Cu(II) and Zn(II) complexes of 2-((1H-benzo[d]imidazol-1-yl)(phenyl) methyl)hydrazinecarboxamide (BIBS) and 2-((1H-benzo[d]imidazol-1-yl)(phenyl) methyl) hydrazine-carbothioamide (BIBTS) were synthesized and characterized by elemental analysis, IR, 1H NMR, 13C NMR, mass, electronic spectra, magnetic moment, molar conductance and EPR studies. The complexes were found to have general formulae [M(BIBS)2Cl2] and [M(BIBTS)2Cl2] [M = Co(II), Ni(II), Cu(II) and Zn(II)]. The IR results demonstrate that co-ordination sites are the azomethine nitrogen and carbonyl oxygen atom of the ligand BIBS, carbonyl sulphur of the ligand BIBTS. The geometry of the complexes is confirmed by measuring number of bands, their energy positions and intensity by electronic and magnetic moment measurement values. The in vitro biological screening effects of the synthesized compounds were tested against various microbial species and the results show that the metal complexes are more biologically active than the free ligand.

    Keywords

    Mannich base, Metal complexes of benzimidazole, O, N and O, S donor, Antimicrobial activity

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