A new and eco-friendly synthetic strategy for the synthesis of quinoxaline derivatives from various 1,2-diketones and 1,2-diamines using Lewis acid-surfactant-combined Fe(DS)3 as a water stable catalyst is described. Use of water as reaction medium rendered this procedure cost-effective and environmentally benign. In addition to its efficiency and simplicity, this method provided high yields of biologically potent quinoxalines in shorter reaction time. This work not only may lead to environmentally benign systems but also will provide a new aspect of organic chemistry in water.
1,2-Diketones, 1,2-Diamines, Lewis acid-surfactant-combined catalyst and Aqueou medium