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  • Chem Sci Trans., 2016, 5(4),  pp 866-875  

    DOI:10.7598/cst2016.1262

    Research Article

    One Pot Green Synthesis of Pyrazolo[4, 3-d]pyrimidin-7(4H)-ones and Dihydroquinazolin-4(1H)-ones Derivatives Catalyzed by Efficient Recyclable Amberlite IR-120H Resin

  • ISMAIL, GANGADHAR THALARI, TASNEEM MOHAMMED and BHASKAR KUTHATI*
  • Department of Chemistry, Osmania University, Hyderabad-500007, India
    Department of Chemistry, Nizam College, Osmania University, Hyderabad-500001, India
    IbnSina National College for Medical Studies, Jeddah-21418, Kingdom of Saudi Arabia
  • Abstract

    Cyclic condensation reactions of various aromatic and heterocyclic aldehydes have been carried out with 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide and o-aminobenzamide by using Amberlite IR-120H resin to afford the corresponding pyramidin-ones and quinazolin-ones in good yield. Further it is of interest to note that cyclisations in catalyzed media are dramatically accelerated to afford pyrazolo[4,3-d] pyrimidin-7(4H)-ones and dihydroquinazolin-4(1H)-ones. This procedure works efficiently in various concentrations of amberlite IR-120H resin and different solvent media under reflux conditions. In the end the catalyst has been recovered and reused up to four cycles without significant loss of activity

    Keywords

    5-Arylpyrazolo[4,3-d]pyrimidin-7(4H)-ones, 2-aryldihydroquinazoline-4(1H)-one, 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide, o-aminobenzamides and amberlite IR-120H resin

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