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  • Chem Sci Trans., 2016, 5(3),  pp 619-626  

    DOI:10.7598/cst2016.1263

    Research Article

    Voltammetric Detection of Trimethoprim at CTAB Modified Carbon Paste Electrode

  • C. T. RAMYA KUMARI, G.P. MAMATHA* and H. M. SANTHOSH
  • Department of P.G. Studies and Research in Pharmaceutical Chemistry, Kadur Post Graduate center, Kuvempu University, Karnataka (S), India
  • Abstract

    Cationic surfactant, cetyl trimethylammonium bromide (CTAB) modified carbon paste electrode was fabricated and it was applied to determine the electrochemical response of trimethoprim (TMP). The modified electrode shows excellent electrocatalytic activity towards the oxidation of TMP in phosphate buffer solution (PBS) of pH 3.0 by cyclic voltammetric and differential pulse voltammetric techniques. Cyclic voltammetric parameters such as pH, scan rate, concentration and effect of surfactant on TMP were studied. The analyte showed one well-resolved irreversible oxidation peak at around +1.17 V, which served as the analytical response. The scan rate study reveals that the electrode process was controlled by diffusion of the analyte. The limit of detection (LOD) and limit of quantification (LOQ) of trimethoprim were found to be 0.15 μ M and 0.455 μ M, respectively. CTAB modified carbon paste electrode showed excellent electrocatalytic effect towards the detection of trimetheoprim

    Keywords

    Cyclic voltammetry, Trimethoprim, Cetyl trimethylammonium bromide, Carbon paste electrode

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