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  • Chem Sci Trans., 2016, 5(4),  pp 1042-1048  

    DOI:10.7598/cst2016.1285

    Research Article

    Synthesis, Spectral Characterization and Biological Screening of Potentially Active 1, 3-Diones and its Transition Metal Complexes

  • D. M. SURYAWANSHI, V. D. INGLE, N. A. BHISE, A. S. RAJBHOJ and S. T. GAIKWAD*
  • Department of Chemistry, Rayat Shikshan Sanstha?s Annasaheb Awate College, Manchar (M.S.), 410 503, India
    Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad (M.S.), 431 004, India
  • Abstract

    1-(2-Hydroxyphenyl)-3-propane-1, 3-diones 4(LA-LB) and its metal complexes 5(a-e) have been newly synthesized from substituted 2-hydroxyacetophenones 1(A-B) and aromatic acids 2(A-B) under ultrasound irradiation method at low temperature. These compounds were characterized by FT-IR, UV-Vis., 1H-NMR, 13C-NMR, mass spectroscopy and magnetic measurement. The stoichiometry of the complexes was found 1:2 (metal:ligand). The physicochemical data suggested octahedral geometry for all the complexes. The ligands 4(LA-LB) and their metal complexes 5(a-e) were screened for in vitro antibacterial activity against S. aureus, B. subtilis, E. coli and P. aeruginosa compared with tetracycline and chloramphenicol as a standard drugs. The results are in good agreement with respect to activity of free ligand and its metal complexes. Reactions under ultrasonic irradiation had improved yield.

    Keywords

    1, 3-Diones, Metal complexes, Ultrasound irradiations, Magnetic measurements, Antibacterial screening

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