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  • Chem Sci Trans., 2016, 5(4),  pp 1082-1089  

    DOI:10.7598/cst2016.1288

    Research Article

    Synthesis and Characterization of Potential Impurities in Levothyroxine

  • DEEPAK PANMANAD*, MANDAR JOSHI, RAHUL PATIL, PRIYANKA JOSHI and VIDYADHAR JADHAV
  • Prof. Dr. S. C. Bhattacharya Organic Synthesis Laboratory, VerGo Pharma Research Lab. Pvt. Ltd., Plot B5, Phase 1A, Verna Industrial Estate, Verna, Salcette, Goa-403722, India
  • Abstract

    Five potential USP grade levothyroxine impurities i.e. N-methyl amide (2), T4-amine O-methyl (7), T4-acetamide (9), N-acyl-T4 (10) and N-formyl-T4 (11) have been synthesized. Each Levothyroxine impurity was characterized based on their spectral data (IR, 1H NMR and Mass). The synthesis and characterisation of the Levothyroxine impurities are discussed

    Keywords

    Levothyroxine, Impurity, Synthesis, Characterization, Decarboxylation

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