Abstract

Five potential USP grade levothyroxine impurities i.e. N-methyl amide (2), T4-amine O-methyl (7), T4-acetamide (9), N-acyl-T4 (10) and N-formyl-T4 (11) have been synthesized. Each Levothyroxine impurity was characterized based on their spectral data (IR, ¹H NMR and Mass). The synthesis and characterisation of the Levothyroxine impurities are discussed

Keywords

Levothyroxine, Impurity, Synthesis, Characterization, Decarboxylation