• image 01
    Volume 1, No.1, 2012
  • image 02
    Volume 1, No.2, 2012
  • image 01
    Volume 1, No.3, 2012
  • image 02
    Volume 2, No.1, 2013
  • image 02
    Volume 2, No.2, 2013
  • image 02
    Volume 2, No.S1, 2013
  • image 02
    Volume 2, No.3, 2013
  • image 02
    Volume 2, No.4, 2013
  • image 02
    Volume 3, No.1, 2014
  • image 02
    Volume 3, No.2, 2014
  • Volume 3, No3
    Volume 3, No.3, 2014
  • Volume 3, No4
    Volume 3, No.4, 2014
  • Volume 4, No1
    Volume 4, No.1, 2015
  • Volume 4, No2
    Volume 4, No.2, 2015
  • Volume 4, No3
    Volume 4, No.3, 2015
  • Volume 4, No4
    Volume 4, No.4, 2015
  • Volume 5, No1
    Volume 5, No.1, 2016
  • image 01
  • image 02
  • Login|Register

  • HomeTable of ContentsList of ArticlesAbstract

    Chem Sci Trans., 2016, 5(4),  pp 1082-1089  

    DOI:10.7598/cst2016.1288

    Research Article

    Synthesis and Characterization of Potential Impurities in Levothyroxine

  • DEEPAK PANMANAD*, MANDAR JOSHI, RAHUL PATIL, PRIYANKA JOSHI and VIDYADHAR JADHAV
  • Prof. Dr. S. C. Bhattacharya Organic Synthesis Laboratory, VerGo Pharma Research Lab. Pvt. Ltd., Plot B5, Phase 1A, Verna Industrial Estate, Verna, Salcette, Goa-403722, India

    • Abstract

    Five potential USP grade levothyroxine impurities i.e. N-methyl amide (2), T4-amine O-methyl (7), T4-acetamide (9), N-acyl-T4 (10) and N-formyl-T4 (11) have been synthesized. Each Levothyroxine impurity was characterized based on their spectral data (IR, 1H NMR and Mass). The synthesis and characterisation of the Levothyroxine impurities are discussed

    Keywords

    Levothyroxine, Impurity, Synthesis, Characterization, Decarboxylation

    HISTORY

  • Received 16 June 2016
  • Accepted 26 June 2016
  • Indexing Metadata
  • How to cite item
  • Review Policy
  • Rights & Permissions
  • Citation Alert
  • Order Reprints

    • This article has been viwed 723 times

      

    Citations for this article 0

      

    No Citations