• image 01
    Volume 1, No.1, 2012
  • image 02
    Volume 1, No.2, 2012
  • image 01
    Volume 1, No.3, 2012
  • image 02
    Volume 2, No.1, 2013
  • image 02
    Volume 2, No.2, 2013
  • image 02
    Volume 2, No.S1, 2013
  • image 02
    Volume 2, No.3, 2013
  • image 02
    Volume 2, No.4, 2013
  • image 02
    Volume 3, No.1, 2014
  • image 02
    Volume 3, No.2, 2014
  • Volume 3, No3
    Volume 3, No.3, 2014
  • Volume 3, No4
    Volume 3, No.4, 2014
  • Volume 4, No1
    Volume 4, No.1, 2015
  • Volume 4, No2
    Volume 4, No.2, 2015
  • Volume 4, No3
    Volume 4, No.3, 2015
  • Volume 4, No4
    Volume 4, No.4, 2015
  • Volume 5, No1
    Volume 5, No.1, 2016
  • image 01
  • image 02
  • Login|Register
  • Chem Sci Trans., 2013, 2(1),  pp 1-4  

    DOI:10.7598/cst2013.129

    Research Article

    Synthesis and Characterization of Fused Pyrimido-pyrimidine Dicarbonitriles and their Antibacterial Activity

  • G. S.WAGHMARE, S. B. JUNNE, S. D. SHINDE, A. S. WAGHAMARE and S.V. KUBERKAR
  • Organic Synthesis Laboratory, Post Graduate Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-05 (M.S.), India
  • Abstract

    Novel heterocyclic compounds containing pyrimido-pyrimidine moiety have been synthesized by the reaction of 2,4-diamino-6-(4-substituted phenyl)pyrimidine-5-carbonitrile with bis-(-methylthio)methylene malanonitrile in presence of anhydrous K2CO3 to yield 6-amino-4-imino-8-(-4-substituted phenyl)-2-(methylthio) 4(H) pyrimido[1,2-b]pyrimidine-3,7-dicarbonitrle. The structure of pyrimido-pyrimidine dicarbonitriles have been characterized by using IR and 1H NMR spectroscopy. These compounds were screened for their antibacterial activity.

    Keywords

    2,4-Diamino-6-(4-substituted phenyl)pyrimidine-5-carbonitrile, Bis-(methylthio)-methylene malanonitrile, Anhydrous K2CO3, Antibacterial activity, Penicillin

    This article has been viwed 3007 times

      

    Citations for this article 4

      

    Download Citations