A series of 5-(pyridin-4-yl)-3-thioacetamide-1,2,4-triazoles (4a-o), was synthesized, characterized and evaluated for screening antibacterial and antifungal activities on microorganisms, respectively on five bacteria and and Candida tropicalis. The structures of original compounds were confirmed by analytical and spectroscopic (FT-IR, 1H NMR and 13C NMR) methods and elemental analysis. Both the antibacterial and antifungal activities and MIC values of compounds were reported. Among the tested compounds, the most effective compound providing a MIC values of 64 µg mL-1 are 4a,b aganist B. Subtilis and S. Typhimurium and 4o against E. Coli only.
Triazole, Acetamido, Antimicrobial activity