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  • Chem Sci Trans., 2012, 1(1),  pp 226-232  

    DOI:10.7598/cst2012.130

    Research Article

    Synthesis and Antimicrobial Activity of Some New 5-(Pyridin-4-yl)-3-thioacetamido-1,2,4-triazole

  • M.KARAARSLAN1, P.KOPARIR2*, A.CANSIZ3, C.OREK3 and O.SAP3
  • 1Department of Chemistry, Forensic Medicine Institute, TR-4400, Malatya, Turkey
    2Department of Chemistry, Aksaray, Universty, TR-68100, Aksaray, Turkey
    3Department of Chemistry, Firat, University, TR-23119 Elazig, Turkey
  • Abstract

    A series of 5-(pyridin-4-yl)-3-thioacetamide-1,2,4-triazoles (4a-o), was synthesized, characterized and evaluated for screening antibacterial and antifungal activities on microorganisms, respectively on five bacteria and and Candida tropicalis. The structures of original compounds were confirmed by analytical and spectroscopic (FT-IR, 1H NMR and 13C NMR) methods and elemental analysis. Both the antibacterial and antifungal activities and MIC values of compounds were reported. Among the tested compounds, the most effective compound providing a MIC values of 64 g mL-1 are 4a,b aganist B. Subtilis and S. Typhimurium and 4o against E. Coli only.

    Keywords

    Triazole, Acetamido, Antimicrobial activity

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