Abstract

A series of structurally new coumarin clubbed carbamodithioate derivatives 7a-t were designed and synthesized by multistep synthesis using biocatalyst Baker's Yeast. All the new compounds were characterized by mass, ¹H and ¹³C NMR and elemental analysis. Furthermore, compound 7a-t evaluated for their in vitro antibacterial and antitubercular activities. The results indicated that some of the synthesized compounds posses promising antimicrobial activity against some gram-positive and gram-negative bacteria. Some compounds displayed good activity against Mycobacterium tuberculosis H37 Rv as compared to standard drug.

Keywords

Baker's yeast, Carbamodithioate, Coumarin, Antibacterial activity, Antitubercular activity