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  • Chem Sci Trans., 2016, 5(4),  pp 886-893  

    DOI:10.7598/cst2016.1303

    Research Article

    Synthesis and Pharmacology Evolution of New Coumarin Clubbed Carbamodithioate Moiety using Biocatalyst

  • KEYURKUMAR A. KAMANI and KANUPRASAD D. PATEL*
  • V. P. & R. P. T. P. Science College, Sardar Patel University, Vallabh Vidyanagar-388 120, Gujarat, India
  • Abstract

    A series of structurally new coumarin clubbed carbamodithioate derivatives 7a-t were designed and synthesized by multistep synthesis using biocatalyst Baker's Yeast. All the new compounds were characterized by mass, 1H and 13C NMR and elemental analysis. Furthermore, compound 7a-t evaluated for their in vitro antibacterial and antitubercular activities. The results indicated that some of the synthesized compounds posses promising antimicrobial activity against some gram-positive and gram-negative bacteria. Some compounds displayed good activity against Mycobacterium tuberculosis H37 Rv as compared to standard drug.

    Keywords

    Baker's yeast, Carbamodithioate, Coumarin, Antibacterial activity, Antitubercular activity

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