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  • Chem Sci Trans., 2016, 5(4),  pp 1056-1062  

    DOI:10.7598/cst2016.1310

    Research Article

    New 2, 2-Dichloroacetamidines with Heterocyclic Fragments

  • PAVLO V. ZADOROZHNII*, IHOR O. POKOTYLO, VADYM V. KISELEV and ALEKSANDR V. KHARCHENKO
  • Department of Organic Substances and Pharmaceutical Preparations, Ukrainian State University of Chemical Technology, Gagarin Ave., 8, Dnipro 49005, Ukraine
  • Abstract

    Based on easily available N-amidoalkylated derivatives of 2-aminobenzimidazole, 2-aminobenztiazole and 2-amino-1,3,4-oxadiazole, reacting with an excess of highly basic amines, corresponding N-hetaryl-2,2-dichloroacetamidines were obtained. The reaction proceeds in anhydrous dioxane and is followed by dehydrochlorination of substrate and replacing therein the amide moiety with an amine one. The structures of the synthesized compounds have been fully characterized by IR, 1H NMR spectroscopy, mass spectrometric data and elemental analysis

    Keywords

    Hetarylamidine, Benzimidazole, Benzthiazole, 1,3,4-Oxadiazole

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