• image 01
    Volume 1, No.1, 2012
  • image 02
    Volume 1, No.2, 2012
  • image 01
    Volume 1, No.3, 2012
  • image 02
    Volume 2, No.1, 2013
  • image 02
    Volume 2, No.2, 2013
  • image 02
    Volume 2, No.S1, 2013
  • image 02
    Volume 2, No.3, 2013
  • image 02
    Volume 2, No.4, 2013
  • image 02
    Volume 3, No.1, 2014
  • image 02
    Volume 3, No.2, 2014
  • Volume 3, No3
    Volume 3, No.3, 2014
  • Volume 3, No4
    Volume 3, No.4, 2014
  • Volume 4, No1
    Volume 4, No.1, 2015
  • Volume 4, No2
    Volume 4, No.2, 2015
  • Volume 4, No3
    Volume 4, No.3, 2015
  • Volume 4, No4
    Volume 4, No.4, 2015
  • Volume 5, No1
    Volume 5, No.1, 2016
  • image 01
  • image 02
  • Login|Register
  • Chem Sci Trans., 2017, 6(1),  pp 50-56  

    DOI:10.7598/cst2017.1316

    Research Article

    Regioselective Synthesis of Spiro-2-aminopyrimidinone Derivatives in Ionic Liquid as Green Solvent

  • U. S. SISODIA, S. KHOTHARI and S. AMETA
  • Pacific University, Udaipur, Rajasthan-313024, India
  • Abstract

    An interesting regioselectivity was investigated for the synthesis of spiro-2-aminopyrimidinones-5-carbonitrile (4a-e) by the multicomponent condensation of cyclic ketones (1a-d) , alkyl cyanoacetates (2) and various guanidine salts (3) using 3-butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate ([BMIM][BF4]) as ionic liquid. Existence of two possible potentially active centers i.e. -CN and ?COOR groups in the intermediate to Michael adduct results in possibility of formation of two region-isomeric products i.e. spiro-2-aminopyrimidinones-5-carbonitrile (4a-e) or spiro-2-amino-4-imino-pyrimidin-5-carboxylic acid alkyl ester (5). High regioselectivity was displayed with exclusive formation of compound (4a-e) which was further confirmed by spectral studies

    Keywords

    Regioselectivity, Spiro-2-aminopyrimidinones-5-carbonitrile, Ionic liquid, Green solvent

    This article has been viwed 306 times

      

    Citations for this article 0

      

    No Citations