• image 01
    Volume 1, No.1, 2012
  • image 02
    Volume 1, No.2, 2012
  • image 01
    Volume 1, No.3, 2012
  • image 02
    Volume 2, No.1, 2013
  • image 02
    Volume 2, No.2, 2013
  • image 02
    Volume 2, No.S1, 2013
  • image 02
    Volume 2, No.3, 2013
  • image 02
    Volume 2, No.4, 2013
  • image 02
    Volume 3, No.1, 2014
  • image 02
    Volume 3, No.2, 2014
  • Volume 3, No3
    Volume 3, No.3, 2014
  • Volume 3, No4
    Volume 3, No.4, 2014
  • Volume 4, No1
    Volume 4, No.1, 2015
  • Volume 4, No2
    Volume 4, No.2, 2015
  • Volume 4, No3
    Volume 4, No.3, 2015
  • Volume 4, No4
    Volume 4, No.4, 2015
  • Volume 5, No1
    Volume 5, No.1, 2016
  • image 01
  • image 02
  • Login|Register
  • Chem Sci Trans., 2016, 5(4),  pp 1068-1081  

    DOI:10.7598/cst2016.1319

    Research Article

    Identification of Novel Triazole Based Indoles as Lead Molecules against Enzyme Mediated Inflammation

  • PARTEEK PRASHER
  • University of Petroleum and Energy Study, PO Bidholi, Uttrakhand, Dehradun- 248007, India
  • Abstract

    A new set of compounds containing indole nucleus appended with carefully selected amino acids via atriazole linker are identified. These compounds are found to be effective against the enzymes responsible for inflammation. The in vitro enzyme immunoassay studies on the test compounds indicated substantial activities which become amplified for the compounds with free carboxyl group. The kinetic experiments indicated favourable enzyme-drug interactions with 1:1 stoichiometry being the most favoured. The in vivo experiments on these compounds indicated the acceptable limits of toxicity compared to the control. All these findings were in close coordination with the docking investigations

    Keywords

    5LOX, COX-1/2, MIC, Inhibition, Isothermal titration calorimetry

    This article has been viwed 407 times

      

    Citations for this article 0

      

    No Citations