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  • Chem Sci Trans., 2017, 6(1),  pp 69-76  

    DOI:10.7598/cst2017.1320

    Research Article

    Electrochemical Determination of Letrozole in Pharmaceutical Formulations by Advanced Voltammetric Techniques

  • ANUBHA SHARMA, K. K. JHANKAL and D. K. SHARMA*
  • Electrochemical Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur (Rajasthan)- 302004, India
  • Abstract

    Electrochemical studies of letrozole by voltammetric techniques were carried out. The letrozole gave one well-defined reduction peak at -0.4 V to -0.5 V vs. Ag/AgCl electrode in Britton Robinson buffer BR of pH 7.0. Under optimized conditions, a linear response was obtained between 3.5x10-6 M and 1.0x10-4 M in aqueous media for square wave and differential pulse cathodic adsorptive stripping voltammetric techniques. The electrochemical process was diffusion controlled. The value of limit of detection (LOD) were 3.77x10−7 mol L−1 and 2.52x10-7 mol L−1 for SWCAdSV and DPCAdSV respectively.

    Keywords

    Letrozole, Anti-Cancer, Cyclic voltammetry, Glassy carbon electrode, Square wave voltammetry

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