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  • Chem Sci Trans., 2016, 5(4),  pp 1063-1067  

    DOI:10.7598/cst2016.1321

    Research Article

    Differential Spectrophotometric Method for Determination of Florfenicol

  • MOHAMMED MUTASIM ELIMAM, SHAZA WAGIEALLA SHANTIER andELRASHEED AHMED GADKARIEM
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, P.O. Box 1996, Khartoum, Sudan
  • Abstract

    Simple, selective and accurate differential first derivative spectrophotometric method (ΔD1) was developed for the determination of florfenicol in bulk and pharmaceutical formulation. The developed method was based on measuring the ΔD1 of florfenicol in alkaline solutions against its aqueous solutions as blank. Beer's law was found to be linear over the concentration range 3-15 μg/mL with good correlation coefficient (0.999). The selectivity of the method was proved through freedom from interferences

    Keywords

    Differential, First derivative, Florfenicol, Alkaline solutions

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