• image 01
    Volume 1, No.1, 2012
  • image 02
    Volume 1, No.2, 2012
  • image 01
    Volume 1, No.3, 2012
  • image 02
    Volume 2, No.1, 2013
  • image 02
    Volume 2, No.2, 2013
  • image 02
    Volume 2, No.S1, 2013
  • image 02
    Volume 2, No.3, 2013
  • image 02
    Volume 2, No.4, 2013
  • image 02
    Volume 3, No.1, 2014
  • image 02
    Volume 3, No.2, 2014
  • Volume 3, No3
    Volume 3, No.3, 2014
  • Volume 3, No4
    Volume 3, No.4, 2014
  • Volume 4, No1
    Volume 4, No.1, 2015
  • Volume 4, No2
    Volume 4, No.2, 2015
  • Volume 4, No3
    Volume 4, No.3, 2015
  • Volume 4, No4
    Volume 4, No.4, 2015
  • Volume 5, No1
    Volume 5, No.1, 2016
  • image 01
  • image 02
  • Login|Register
  • Chem Sci Trans., 2016, 5(4),  pp 1090-1095  

    DOI:10.7598/cst2016.1323

    Research Article

    Synthesis and Antibacterial Screening of 4-Arylidene-5-oxo-imidazoles having Carboxamide Linkage with 5-(benzofuran-2-yl)-1-phenylpyrazole Moiety

  • MOHAMMAD IDREES* R. D. NASARE and N. J. SIDDIQUI
  • Department of Chemistry, Government Institute of Science, Nagpur-440001, Maharashtra, India
    Department of Chemistry, Government Science College, Gadchiroli- 442605, Maharashtra, India
  • Abstract

    Synthesis of 5-(H/Br benzofuran-2-yl)-1-phenyl 1H-pyrazole-3-carbohydrazides (1a-b) and condensation with different 4-(arylidene)-2 phenyloxazol-5(4H)-one (2a-g) in acetic acid medium, a series of 5-(H/Br benzofuran -2-yl)-N-(4-arylidene-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl)-1-phenyl-1H-pyrazole-3-carboxamide derivatives (3a-g) have been carried out. Different 4-(arylidene)-2-phenyloxazol-5(4H)-one (2a-g) were synthesized from substituted benzaldehyde with hippuric acid. The structures of the novel compounds were elucidated on the basis of elemental analysis and spectral studies such as FT-IR, 1H NMR, further supported by Mass spectra. The synthesized 5-(benzofuran-2-yl)-N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-1-phenyl-1H-pyrazole-3-carboxamide (3a) was assayed in vitro for their antimicrobial activity at different concentration against four different bacterial strains namely B. thurengienesis, S. aureus, E. Coli and E. Areogenes. The investigation of antibacterial screening reveals that 3a exhibited excellent activity against Gram +ve and poor activity against Gram ?ve bacteria when compared to chloramphenicol as standard drug

    Keywords

    5-Oxo imidazole, 4-Arylidene oxazolones, Carbohydrazides

    This article has been viwed 549 times

      

    Citations for this article 0

      

    No Citations