Synthesis of 5-(H/Br benzofuran-2-yl)-1-phenyl 1H-pyrazole-3-carbohydrazides (1a-b) and condensation with different 4-(arylidene)-2 phenyloxazol-5(4H)-one (2a-g) in acetic acid medium, a series of 5-(H/Br benzofuran -2-yl)-N-(4-arylidene-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl)-1-phenyl-1H-pyrazole-3-carboxamide derivatives (3a-g) have been carried out. Different 4-(arylidene)-2-phenyloxazol-5(4H)-one (2a-g) were synthesized from substituted benzaldehyde with hippuric acid. The structures of the novel compounds were elucidated on the basis of elemental analysis and spectral studies such as FT-IR, 1H NMR, further supported by Mass spectra. The synthesized 5-(benzofuran-2-yl)-N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-1-phenyl-1H-pyrazole-3-carboxamide (3a) was assayed in vitro for their antimicrobial activity at different concentration against four different bacterial strains namely B. thurengienesis, S. aureus, E. Coli and E. Areogenes. The investigation of antibacterial screening reveals that 3a exhibited excellent activity against Gram +ve and poor activity against Gram ?ve bacteria when compared to chloramphenicol as standard drug
5-Oxo imidazole, 4-Arylidene oxazolones, Carbohydrazides