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  • Chem Sci Trans., 2017, 6(2),  pp 219-226  

    DOI:10.7598/cst2017.1326

    Research Article

    Microwave Assisted Synthesis and Biological Evaluation of 1, 2, 4-Triazolo[1, 5-a]pyrimidines

  • PARTHIV KANTILAL CHAUDHARI
  • Government Science College, Chemistry Department, Vankal-394430 Ta:- Mangrol, Di:- Surat, India
  • Abstract

    A microwave assisted synthesis of three new series of of 1, 2, 4-triazolo[1, 5-a]pyrimidines (PK-101 to PK-110) has been synthesized by the mixture of 5-(methylthio)-2H-1,2,4-triazol-3-amine (0.01 mol), 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione (0.01 mol) and an appropriate aromatic aldehyde (0.01 mol) in ethanol (5 mL) was irradiated under microwave conditions at 120 oC for 10-15 min. The structures of all the newly synthesized compounds are elucidated by FT-IR, mass spectra, 1H NMR and elemental analysis. The newly synthesized compounds are subjected to various biological activities viz., antimicrobial, antimycobacterial, anticancer and antiviral.

    Keywords

    1,2,4-Triazolo[1,5-a]pyrimidines, Antimicrobial activity, Anticancer, Antiviral, Antituberculosis activity, Antimycobacterial activity

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