Abstract

Reaction of the pregnane derivatives (1), (2), (3) and (4) with hydrazines, afforded the pyrazoline derivatives, (5a,b), (6a,b), (7a, b) and (8a,b) respectively, compound (1) and (3) reacted with urea and thiourea and give pyrimidine and pyrimidinethione derivatives (9a,b) and (10a,b) respectively. Also, compound (1) reacted with hydroxylamine hydrochloride and guanidine carbonate in refluxing ethanol and yield the isoxazole derivative (11) and the aminopyrimidine (12). Evaluation of the biological activity of the synthesized compounds, were carried and they had a significant effects as antibiotics and gram positive bacteria and gram negative bacteria.

Keywords

Pyrimidine, Pyrazoline, Isoxazoline