An Efficient Three Component Synthesis of 1<i>H</i>-Indazolo[2, 1-<i>b</i>]phthalazine-triones Catalyzed by Orthophosphoric Acid in Water-Phenol System

Chem Sci Trans., 2017, 6(2), pp 304-310

DOI:10.7598/cst2017.1345

Research Article

An Efficient Three Component Synthesis of 1H-Indazolo[2, 1-b]phthalazine-triones Catalyzed by Orthophosphoric Acid in Water-Phenol System

MANURI BRAHMAYYA*, REDDYMASU SREENIVASULU, CH.CHINA SATYANARAYANA, BATTULA VENKATESWARA RAO, K. N. SANTHI, M. V. RAGHUPATHIRAJU and M. VIJAYA

Department of Engineering Chemistry, Andhra University, Visakhapatnam-530 003, A.P., India
Department Environamental Engineering Safety and Health, Hungkuang University, Taichung, Taiwan
Department of Chemistry, Acharya Nagarjuna University, Guntur, India
S K B R College, Department of Chemistry, Amalapuram, East Godavari Dist, A.P, India
Chaitanya women?s College, Department of Zoology, Gajuwaka, Viskhapatnam, India
Department of Chemistry, D.N.R.College, Bhimavaram, West Godavari, A.P, India

Abstract

Simple method for the synthesis of 1H-Indazolo [2,1-b]phthalazine-triones via one pot three component condensation of phthalhydrazide, aldehyde and dimedone catalyzed by orthophosphoric acid in water-phenol system is reported. This synthetic procedure proves with extremely lower reaction timings, high yields, recyclable of catalyst and green solvent system.