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  • Chem Sci Trans., 2017, 6(3),  pp 399-404  

    DOI:10.7598/cst2017.1346

    Research Article

    Selective Alkylation of Aromatic Five-Membered Heterocyclic Molecules

  • D. SAMSONU1*, M. BRAHMAYYA1,2, U. VIPLAVA PRASAD1 and G. RAVI KUMAR2
  • 1Department of Organic Chemistry and Foods, Drugs, Water Analysis, Andhra University, Visakhapatnam ?530003, India
    2Department of Engineering Chemistry, Andhra University, Visakhapatnam, India
  • Abstract

    A series of alkylated heterocycles were selectively prepared from the corresponding heterocyclic compounds with the phase transfer catalyst tetraoctylammoniumbromide (TOAB), as catalyst at 100 0C temperatures. This present protocol demonstrates a simple alkylation procedure and has an extensive range of applicability and was applied to the furan, thiophene and pyrrole providing as another method for the research of these drug intermediates

    Keywords

    Catalysis, Heterocyclic molecules, Methylation, Selectivity, Methodology

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