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  • Chem Sci Trans., 2017, 6(3),  pp 485-491  

    DOI:10.7598/cst2017.1356

    Research Article

    Synthesis and Characterization of 1,3,4-Oxadiazoles Derivatives from 1,2,3,4-Tetrahydroisoquinoline and their Bioevalution (Antibacterial & Antifungal)

  • N. KRISHNA RAO1, M. SURENDRA BABU2*, M. V. BASAVESWARA RAO1, R. KESHAVI3, N. SUNDARA RAO3, Y. L. N. MURTHY3 and SHAIK LAKSHMAN4
  • 1Chemistry Department, Krishna University, Machilipatnam, India
    2Department of Chemistry, GITAM University, Hyderabad, India
    3Department of Organic Chemistry, Andhra University, Visakhapatnam, India
    4Department of Chemistry, GITAM University, Visakhapatnam, India
  • Abstract

    New derivatives of 1,3,4-oxadiazole, synthesized by the condensation of different substituted benzoic acids with 2-(1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl) acetohydrazide using SOCl2 as well as POCl3 as cyclization reagents. Ethyl-2-(1-phenyl-1,2,3,4-tetrahydroisoquinoline)-ethaonate was synthesized from 1,2,3,4-Tetrahydroisoquinoline and it was converted to the 2-(1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl)acetohydrazide. This compound is the key intermediate for the 1,3,4-oxadiazole compounds. All the synthesized molecules were characterized by advanced spectral data and also studied their biological activity.

    Keywords

    1,2,3,4-Tetrahydroisoquinoline, Ethyl-2-(1-phenyl-3,4-dihydro isoquinoline-2(1H)-yl) acetate, 2-(1-Phenyl-3,4-dihydroisoqunoline-2(1H)-yl)acetohydrazide, 1,3,4-Oxadiazole, Cyclization re

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