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  • Chem Sci Trans., 2017, 6(2),  pp 330-338  

    DOI:10.7598/cst2017.1371

    Research Article

    Adsorptive Stripping Voltammetric Determination of Bupropion in Pharmaceuticals

  • RAM LAL SAINI, SACHIN DOI, K. K. JHANKAL and D. K. SHARMA*
  • Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur (Rajasthan)- 302004, India
  • Abstract

    Electrochemical studies of bupropion by voltammetric techniques were carried out. The bupropion gave one well-defined reduction peak at -1.2 to -1.3V vs. Ag/AgCl electrode in Britton Robinson buffer BR of pH 9. Under optimized conditions, a linear response was obtained between 1.0x10-6 M to 5.6x10-6 M in aqueous media for square wave and differential pulse cathodic adsorptive stripping voltammetric techniques. The electrochemical process was diffusion controlled. The value of limit of detection (LOD) are 1.28x10-7 mol L-1 and 7.79x10-7 mol L-1 for SWCAdSV and DPCAdSV respectively.

    Keywords

    Bupropion, Anti-depressant, Cyclic voltammetry, Glassy carbon electrode, Square wave voltammetry

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