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  • Chem Sci Trans., 2017, 6(3),  pp 411-416  

    DOI:10.7598/cst2017.1397

    Research Article

    Synthesis Characterisation and Antimicrobial Activity of N´-(2-Chloroquinolin-3-yl)methylene)- isonicotinohydrazide

  • R. A. SHASTRI* and A. M. DODKEY
  • Post Graduate Department of Chemistry, S.B.E.S. College of Science, Aurangabad-431001, India
  • Abstract

    A series of novel N`-(2-chloro-substituted quinolin-3-yl)methylene)isonicotinohydrazide (3a-h) were prepared by condensation of 2-chloro-3-formylquinoline (1a-h) with isonicotinohy-drazide (2) in the presence of catalytic quantity of acetic acid in methanol under reflux in good yield. Newly synthesized compounds were characterized by IR, 1H NMR and mass. The newly synthesized compound (3a-h) has been screened for their antibacterial and antifungal activities. All compounds exhibited significant antibacterial and antifungal activity.

    Keywords

    2-Chloro-3-formylquinoline, Isonicotinohydrazide, Methanol, Antifungal activity

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