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  • Chem Sci Trans., 2017, 6(4),  pp 679-684  

    DOI:10.7598/cst2017.1408

    Research Article

    Method Development and Validation of Visible Spectroscopic Method for the Estimation of Paroxetine Hydrochloride in Pure and Tablet Dosage Form

  • L. SIVA SHANKER REDDY2, T. RAJKUMAR2 and D. JENNY SUSHMITHA EVANGILINE1
  • 1Department of Pharmaceutical Analysis & Quality Assurance, 2Department of Pharmaceutical Chemistry, Creative Educational Societys College of Pharmacy, Chinnatekur, Kurnool -518218, Andhra Pradesh, India
  • Abstract

    The present research work discusses the development of visible spectroscopic method for the estimation of paroxetine hydrochloride. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λmax) was found to be 538 nm. The validation was performed as per ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The method shows high sensitivity with linearity in the range of 200-600 μg/mL and shows a linear relationship between the absorbance and concentration with coefficient of correlation 0.999. The regression of curve was Y = 0.001x+0.007. The precision of method was found to be good. The percentage recovery was found to be 105.02±0.0832. The optimized method showed good reproducibility and recovery with RSD <2%. The proposed method will be suitable for analysis of paroxetine hydrochloride in bulk as well as pharmaceutical formulations in quality control purpose. It is thus concluded that the proposed method is new, simple, cost effective, safe, accurate, precise and environmental friendly.

    Keywords

    Paroxetine hydrochloride, Visible spectroscopic method, Sensitive, Validation, ICH guidelines

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