The cerium oxide nanoparticles (CeO2 NPs) and M2+ doped CeO2 NPs (M2+ = Zn2+, Ni2+, Cu2+ and Co2+) were prepared through the Azadirachta indica (A. indica) leaf extracts. The x-ray diffraction studies confirmed that synthesized pure and M2+ doped CeO2 NPs were exhibited the cubic structure. The FESEM and TEM images of both pure and M2+ doped CeO2 NPs have exhibited spherical structure. From the EDAX spectral analysis, the elemental compositions were identified. The various functional groups were confirmed by FT-IR spectrum. Photoluminescence spectral analysis, small shift observed for emission of the CeO2 NPs values as compared to that of the transition metal ions doped CeO2 NPs emission values. The antimicrobial studies were performed against a set of gram positive (Staphylococcus aureus and Streptococcus pneumonia) and gram negative (Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Klebsiella pneumonia and Shigelladysenteriae) bacterial and fungal candida albicans strain
CeO2, Antimicrobial activity, FTIR, Photoluminscenance, FESEM, TEM