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  • Chem Sci Trans., 2018, 7(2),  pp 229-239  

    DOI:10.7598/cst2018.1414

    Research Article

    Electrochemical Behaviour and Adsorptive Stripping Voltammetric Determination of Cyclophosphamide

  • PRIYANKA SINHA, SACHIN DOI and D. K. SHARMA*
  • Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur (Rajasthan)-302004, India
  • Abstract

    Electrochemical behaviour of anticancer medication cyclophosphamide was studied in BR buffer of pH 3.0 at glassy carbon electrode using cyclic voltammetry. Cyclophosphamide gave one well defined irreversible reduction peak at potential -1.4V v/s Ag/AgCl reference electrode. The reduction was diffusion controlled and all kinetic parameters were calculated and a reduction mechanism was proposed based on the observed experimental data. Furthermore, differential pulse cathodic adsorptive stripping voltammetry (DPCAdSV) was optimized for determination of cyclophosphamide in bulk form and human urine as biological sample. Good linearity range and obtained LOD and LOQ of 1.1?10-6 M and 3.67?10-6 M respectively indicated about the good sensitivity of developed method.

    Keywords

    Cyclophosphamide, Cyclic voltammetry, Differential pulse cathodic adsorptive stripping voltammetry, Diffusion controlled, LOD and LOQ

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