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  • Chem Sci Trans., 2017, 6(4),  pp 614-618  

    DOI:10.7598/cst2017.1416

    Research Article

    Novel Method for the Quantification of Ropinirole Hydrochloride in Pure API and its Marketed Formulations Using 3-Methyl-2-benzothiazolinone Hydrazone Hydrochloride and p-Dimethylaminocinnamaldehyde as Chromogenic Reagents by Spectrophotometry

  • I. SRIKANTH1*, M. SRILATHA1, P. RATNA KUMARI1, P. V. SURESH2
  • 1Department of Pharmaceutical Analysis, K.C. Reddy Institute of Pharmaceutical Sciences, Jangamguntla Palem, Medikonduru Mandal, Guntur 522 348, India
    2Department of Pharmaceutical Analysis, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur 522 034, India
  • Abstract

    Two novel simple and sensitive spectrophotometric methods in visible region were developed for the estimation of ropinirole hydrochloride (RPH) in pure and its pharmaceutical dosage forms. Method-A based on the oxidative coupling product with 3-methyl-2-benzothiazolinone bydrazone bydrochloride (MBTH) in presence of ferric chloride to give intense blue colored azodye complex having λmax at 680 nm and method-B based on the reaction of p-dimethylamino cinnamaldehyde (PDAC) under acidic media to give yellow colored Schiff base having λmax at 420 nm. Both these methods obey Beers law in the concentration range of 5-50 μg/mL. All variables in these methods are optimized and the reaction mechanisms are presented. No interference was observed from tablet additives and the applicability of these methods was examined by analyzing tablets containing RPH. The proposed methods are precise, accurate and reproducible. It can be extended to the analysis of ropinirole hydrochloride in marketed formulations.

    Keywords

    Chromogen, MBTH, PDAC, Ropinirole hydrochloride, Spectrophotometry

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