• image 01
    Volume 1, No.1, 2012
  • image 02
    Volume 1, No.2, 2012
  • image 01
    Volume 1, No.3, 2012
  • image 02
    Volume 2, No.1, 2013
  • image 02
    Volume 2, No.2, 2013
  • image 02
    Volume 2, No.S1, 2013
  • image 02
    Volume 2, No.3, 2013
  • image 02
    Volume 2, No.4, 2013
  • image 02
    Volume 3, No.1, 2014
  • image 02
    Volume 3, No.2, 2014
  • Volume 3, No3
    Volume 3, No.3, 2014
  • Volume 3, No4
    Volume 3, No.4, 2014
  • Volume 4, No1
    Volume 4, No.1, 2015
  • Volume 4, No2
    Volume 4, No.2, 2015
  • Volume 4, No3
    Volume 4, No.3, 2015
  • Volume 4, No4
    Volume 4, No.4, 2015
  • Volume 5, No1
    Volume 5, No.1, 2016
  • image 01
  • image 02
  • Login|Register
  • Chem Sci Trans., 2017, 6(4),  pp 523-534  

    DOI:10.7598/cst2017.1422

    Research Article

    Synthesis, Characterization and In Vitro Antibacterial Effect of 4H-Benzo[g]chromene Derivatives using Nano-NiO

  • T. CLARINA, G. R. PRIYA DHARSINI and V. RAMA*
  • Department of Chemistry, Sarah Tucker College, Manonmaniam Sundarnar University, Abishekapatti, Tirunelveli -627 012, Tamilnadu, India
  • Abstract

    The domino Knoevenagel cyclocondensation reactions via substituted aldehydes, activated methylene reagent and 2-hydroxy-1, 4-naphthoquinone gives benzo[g]chromenes in presence of nano-NiO using acetonitrile as a solvent at ambient temperature. This method gives the desired products from good to excellent yield. The salient features of this atom economical procedure are ease of manipulation, simpler workup, high yield processing, easy handling, inexpensiveness, reusability of catalyst and tolerance to a wide range of functional groups. The synthesized chromene derivatives are screened for antibacterial activity and antifungal activity using Kirby-Bauer method. The synthesized compounds 3a-3k exhibits significant inhibition to antibacterial and antifungal activity compared with the standard drug Ciprofloxacin and Flucanazole respectively.

    Keywords

    Antibacterial, Knoevenagel condensation, Michael cyclization, Nano-NiO, Simple workup

    This article has been viwed 250 times

      

    Citations for this article 0

      

    No Citations