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  • Chem Sci Trans., 2012, 1(1),  pp 91-102  

    DOI:10.7598/cst2012.143

    Research Article

    Acceleration of Multicomponent Reactions in Aqueous Medium: Multicomponent Synthesis of a 4H-pyran Library

  • A. MOSHTAGHI ZONOUZ*, I. ESKANDARI and D. MOGHANI
  • Department of Chemistry, Faculty of Science, Azarbaijan University of Tarbiat Moallem, Tabriz Iran
  • Abstract

    A combinatorial library of 2-amino-4H-pyran derivatives has been developed by a three-component reaction between aldehyde, malononitrile and -dicarbonyl compounds (ethyl acetoacetate or acetylacetone) in the presence of ammonium acetate in aqueous medium. This protocol couples the benefits of multi-component reaction (MCR) with those of water as solvent for organic transformations, thus facilitating efficient chemical production in an environmentally benign way.

    Keywords

    2-Amino-4H-pyran, One-pot reaction, Multi-component reaction, Aqueous medium.

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