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  • Chem Sci Trans., 2018, 7(1),  pp 89-94  

    DOI:10.7598/cst2018.1441

    Research Article

    A Green Approach for the Synthesis of 2,4-Dihydro-pyrimidinones Using PTSA

  • R. A. SHASTRI* and P. P. JOSHI
  • P.G. Department of Chemistry, S.B.E.S. College of Science, Aurangabad-431001, Maharashtra, India
  • Abstract

    A simple and efficient method has been developed for the one pot cyclocondensation of heterocyclic aldehydes, β-ketoester and urea by using PTSA (p-Toluenesulfonic acid) as catalyst. This method has several advantages of excellent yield, inexpensive, short reaction time, ecofriendly and attractive for large scale synthesis.

    Keywords

    2-Chloro3-formylquinoline, PTSA, Urea, Dihydropyrimidinones

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