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  • Chem Sci Trans., 2018, 7(2),  pp 272-281  

    DOI:10.7598/cst2018.1467

    Research Article

    Differential Pulse Polarography Procedure for the Estimation of Deferoxamine in Pharmaceuticals

  • SALAM A.H. AL-AMERI and BAYAN H.A. AL-AMERI*
  • Department of Chemistry, College of Science, Al-Mustansiriyah University, Baghdad, Iraq
  • Abstract

    A differential pulse polarography procedure has been developed and applied for the determination of deferoxamine in dosage form with DME versus Ag/AgCl. The best peak response was establish at -1.63V in 0.04 M B-R buffer at pH 2 and 0.1 M KCl as supporting electrolyte with two electrons transferred in irreversible process. In the best conditions, Beer?s law was perform with in the concentration range of 0.01- 0.05 μg.mL-1 with a correlation coefficient, r=9985. The obtaining LOD and LOQ was 0.0024 and 0.0081 μg.mL-1, the precision, %RSD ranged between 0.34-1.24%. Another DPP method has been proposed for the estimation as deferoxamine-Fe complex which gave best DDP response at -0.385V in 0.1 M acetate buffer at pH 4 and 0.01 M KCl as supporting electrolyte. The calibration graph was linear at a concentration range 1.2510-6 - 2.510-5 M with r =9985 also a superb analytical merit numbers were found, LOD of 0.710-6 M and the LOQ of 2.3210-6 M with RSD% ranged from 0.27- 0.66%. The formation of this colored complex at 1:1 mole ratio calculated by UV-Vis spectrophotometry at λ max = 468 nm in aqueous medium. The established DPP methods offers excellent analytical figures of merits as well as applied to examine the commercial drug Desferal? vial for the determination of deferoxamine and found to be 490.6 mg/unit compared to the stated value of 500 mg/unit.

    Keywords

    DPP, Deferoxamine, Fe, Complex

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