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  • Chem Sci Trans., 2018, 7(2),  pp 258-264  

    DOI:10.7598/cst2018.1474

    Research Article

    One Pot Multicomponent Synthesis of Novel Thiazolopyrimidines

  • G. VEERA RAGHAVA SHARMA*, A. APPALA NAIDU and B. DEVI
  • GITAM Institute of Technology, GITAM University, Rushikonda, Visakhapatnam-530045, AP, India
  • Abstract

    A novel, solvent-free, simple, eco-friendly and one-pot multicomponent synthesis of various thiazolopyrimidines is studied. Conventional heating the mixture of amine, aldehyde and β-ketoester or 1,3-diketone under solvent free conditions afforded the thiazolopyrimidines compound in good to excellent yields. Further, a boron trifluoride mediated intermolecular cyclization to provide a novel tetra cyclic system is also reported. 1H NMR, 13C NMR, IR and Mass spectroscopy and single crystal analysis were used for identification of these compounds.

    Keywords

    Thiazolopyrimidines, Multicomponent reaction, Solvent-free method, Tetracyclic system, Eco-friendly reactions

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