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  • Chem Sci Trans., 2018, 7(3),  pp 374-383  

    DOI:10.7598/cst2018.1491

    Research Article

    N-(2-Pyridyl)-5-chlorosalicylideneimine Schiff Base and its Tellurium(IV) Complexes: Synthesis, Characterization and In Vitro Biological Activities

  • ANJU MALIK, GOBIND GOYAT, VIKAS, MANISH KUMAR, K.K.VERMA and SAPANA GARG*
  • Department of Chemistry, Maharshi Dayanand University, Rohtak-124001, India
  • Abstract

    Tridentate Schiff base (2-APY-{5-ClSalH}) has been prepared by the condensation of 5-chlorosalicylaldehyde with 2-aminopyridine and further new tellurium(IV) complexes i.e. [TeCl3(2-APY-{5-ClSal})], [RTeCl2(2-APY-{5-ClSal})] and [R2TeCl(2-APY-{5-ClSal})]: where R = p-methoxyphenyl, p-hydroxyphenyl, 3-methyl-4-hydroxyphenyl, of this Schiff base have been synthesized. The characterization of ligand and complexes was carried out by elemental analyses, conductivity measurements, FT-IR and 1H NMR spectral data. The Schiff base ligand as well as their some tellurium(IV) complexes were tested for antimicrobial activities in vitro against Gram-positive bacteria i.e. Staphylococcus aureus and Streptococcus pyogenes and Gram-negative bacteria i.e. Pseudomonas aeruginosa and Escherichia coli and fungi i.e. Candida albicans, Aspergillus niger and Aspergillus clavatus by broth dilution method.

    Keywords

    5-Chlorosalicylaldehyde, Tridentate, Schiff base, 2-Aminopyridine, Antimicrobial activities

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