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  • Chem Sci Trans., 2018, 7(2),  pp 343-347  

    DOI:10.7598/cst2018.1494

    Research Article

    An Efficient and Versatile Method for Synthesis of 1,4-Dihydropyridines at Mild Reaction Conditions

  • VIJENDER GOEL, ANJU BAJWAN, SONU CHAUHAN and SHARDA GOEL*
  • Department of Chemistry, Maharshi Dayanand University, Rohtak-124001, Haryana, India
  • Abstract

    A simple, efficient, versatile and convenient Hantzsch method for synthesis of 1,4-dihydropyridines using ethylacetoacetate, ammonium acetate and substituted arylaldehydes in the presence of tetrabutylammonium hydrogen sulfate (TBAHS) have been reported. Among the popular reported heterogenous solid catalysts, TBAHS has gained high popularity in organic synthesis due to its selectivity, inertness and thermal stability. The method offers advantages such as better yields, short reaction times, a simple work-up procedure, easy isolation of catalyst and reusability of catalyst for several runs.

    Keywords

    1,4-Dihydropyridines, Hantzsch method, Green Chemistry, Tetrabutylammonium hydrogen sulfate, Solvent free synthesis

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