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  • Chem Sci Trans., 2018, 7(3),  pp 390-395  

    DOI:10.7598/cst2018.1497

    Research Article

    Eco-Friendly Synthesis, Spectral, Bio-Potential, DNA Binding and Antituberculosis Activities of Ni(II) And Cu(II) Complexes

  • P. MANIKANDAN*, K. RAJASEKAR, S. BALASUBRAMANIYAN, T. GOMADURAI and B. SATHIYAMOORTHY
  • Department of Chemistry, Government Arts College, Ariyalur-621 713, Tamilnadu, India
  • Abstract

    Microwave technique is one of the eco-friendly techniques used widespread in green synthesis of metal-organic compounds. First transition metal complexes of Ni(II) and Cu(II) synthesized using this technique with organic neutral bidentate ligand isonicotinic acid (INH) and anionic benzoate ion. The synthesized complexes were characterized by micro analytical techniques viz., elemental analysis, metal estimation, magnetic moment (VSM), molar conductance and cyclic voltammeter. The spectral techniques UV-Visible, IR and Far-IR are also used to characterize by the synthesized complexes. The elemental analysis, metal estimation, magnetic moment and UV-Visible spectral data of the complexes indicating their molecular formulae, composition and probable geometry (octahedral for Ni(II) and tetragonally distorted octahedral for Cu(II) complexes). Redox properties and reversibility and feasibility of equilibrium of the synthesized complexes were confirmed by their cyclic voltammogram. Complex formation and metal chelating atom (M-O and M-N) ability of the complexes confirmed by their IR and Far-IR spectral data. The antibacterial and antifungal activities of the ligand (INH) and its complexes were carried out by Agar well diffusion method using Actinobacter, Salmonella, E.coli (bacterial strains) and C. Albicance (Fungal strains). The DNA binding and cleavage studies of the complexes compared with those for pure ligand using Calf-thymus DNA. The complexes can interact with DNA at higher concentration. The antituberculosis of the complexes against M.tuberculosis were performed and compared with the standard and ligand isonicotinic acid.

    Keywords

    Eco-friendly, INH, Benzoate ion, DNA binding, Antituberclosis

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